Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 5.101


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL1chr11_-_65424434-0.837.6e-05Click!
JUNDchr19_-_18253436-0.562.5e-02Click!
JUNBchr19_+_12763295-0.514.3e-02Click!
FOSBchr19_+_506630890.185.1e-01Click!
FOSchr14_+_748152330.039.1e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_221955876 30.697 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr18_+_19706979 22.081 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_-_177378801 21.255 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_-_115682374 20.028 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr18_+_59593591 19.433 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr21_+_29439768 18.760 C21orf7
chromosome 21 open reading frame 7
chr3_+_11153778 18.222 NM_001098213
HRH1
histamine receptor H1
chr17_-_37022465 17.887 NM_005557
KRT16
keratin 16
chr9_-_90456824 15.123 NM_001100111
LOC286238
hypothetical protein LOC286238
chr10_-_88720908 14.991 LOC100133190
hypothetical LOC100133190
chr20_-_17487480 14.718 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr15_-_53996597 14.276 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_+_150000394 14.102 NM_001109974
NM_007286
SYNPO

synaptopodin

chr13_+_77007809 13.551 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr5_+_145297490 13.173 SH3RF2
SH3 domain containing ring finger 2
chr12_-_51173238 12.735 NM_005554
KRT6A
keratin 6A
chr17_-_36996611 12.729 NM_000526
KRT14
keratin 14
chr1_-_36589744 12.542


chr10_+_24795465 12.263 KIAA1217
KIAA1217
chr14_-_104507862 12.107 AHNAK2
AHNAK nucleoprotein 2
chr10_+_24795446 12.043 KIAA1217
KIAA1217
chr2_-_65447267 11.911 SPRED2
sprouty-related, EVH1 domain containing 2
chr3_-_152517204 11.891 NM_023915
GPR87
G protein-coupled receptor 87
chr5_+_147562531 11.795 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr6_-_152744143 11.575 SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_+_47774247 11.528 NM_153838
GPR115
G protein-coupled receptor 115
chr6_+_31190505 11.506 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr20_-_35586366 11.456 NM_001167823
BLCAP
bladder cancer associated protein
chr15_-_38417564 11.274 C15orf52
chromosome 15 open reading frame 52
chr11_+_101488380 11.173 NM_001195045
YAP1
Yes-associated protein 1
chr8_+_22900863 11.048 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr2_+_166034402 11.012 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_181421984 11.003 LAMC2
laminin, gamma 2
chr12_+_13240868 10.925 NM_001423
EMP1
epithelial membrane protein 1
chr6_-_152744022 10.891 SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_+_38319326 10.695 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_34993234 10.663 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr2_-_65447370 10.613 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chrX_+_99786044 10.536 SRPX2
sushi-repeat containing protein, X-linked 2
chr17_+_21131940 10.217 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr12_-_68369322 10.209 NM_152439
BEST3
bestrophin 3
chr1_+_151270301 10.200 NM_003125
SPRR1B
small proline-rich protein 1B
chr20_+_19903778 10.185 RIN2
Ras and Rab interactor 2
chr11_-_65860450 9.997 NM_004292
RIN1
Ras and Rab interactor 1
chr15_+_38849450 9.989 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr5_+_140848905 9.918 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr8_-_38505331 9.775 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr11_-_102219450 9.735 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_207891264 9.675 NM_001017402
LAMB3
laminin, beta 3
chr13_-_37070862 9.627 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr9_+_102231616 9.529 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr11_-_128399218 9.429 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chrX_+_99785818 9.301 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_13240983 9.251 EMP1
epithelial membrane protein 1
chr17_-_36469869 9.137 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr19_-_43955984 9.125 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr12_+_13240987 9.123 EMP1
epithelial membrane protein 1
chr1_-_108032645 8.987 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_57069508 8.902 NM_181727
SPATA12
spermatogenesis associated 12
chr2_+_36777336 8.853 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr14_+_20537253 8.698 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr5_-_54317102 8.660 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr3_-_11585264 8.597 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr9_-_129381086 8.577 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr17_-_7434113 8.506 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr3_+_64645819 8.453 LOC100507098
hypothetical LOC100507098
chr13_-_35327798 8.362 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr14_+_95792299 8.322 NM_000710
BDKRB1
bradykinin receptor B1
chr9_+_676640 8.156


chr16_+_56219802 7.964 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr6_-_169392771 7.924


chr1_+_181422016 7.922 LAMC2
laminin, gamma 2
chrX_-_33139349 7.895 NM_004006
DMD
dystrophin
chr1_+_17719405 7.862 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr4_+_35959638 7.654 NM_001136536
DTHD1
death domain containing 1
chr16_+_70117523 7.639 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr5_+_36644187 7.607 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_35892747 7.558 NM_002185
IL7R
interleukin 7 receptor
chr9_-_116920232 7.458 NM_002160
TNC
tenascin C
chr4_+_120276386 7.440 NM_016599
MYOZ2
myozenin 2
chr14_+_51025604 7.348 NM_001042481
FRMD6
FERM domain containing 6
chr19_-_56215084 7.278 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr7_-_16811131 7.277 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr15_-_68781662 7.249 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_-_33047042 7.182 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr16_-_2848106 7.168 NM_022119
PRSS22
protease, serine, 22
chr4_-_115120251 7.122 NM_024590
ARSJ
arylsulfatase family, member J
chr2_+_113591940 7.075 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr2_+_219180862 6.997 PLCD4
phospholipase C, delta 4
chr9_+_5500544 6.974 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr19_-_52427698 6.958 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr17_-_24068759 6.950 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr1_+_34997928 6.928 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr10_+_118177371 6.882 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr18_+_50646616 6.850 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr3_-_188936941 6.816 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_+_58146721 6.782 NM_000614
CNTF
ciliary neurotrophic factor
chr1_-_221920023 6.772 NM_001143962
CAPN8
calpain 8
chr12_-_56445653 6.751 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_+_20005704 6.748 NAV2
neuron navigator 2
chr18_+_59295123 6.726 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_+_104218487 6.622


chr1_+_181421796 6.601 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr18_-_26996742 6.574 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_-_6298284 6.570 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr9_-_34652629 6.561 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr12_-_15706340 6.511 EPS8
epidermal growth factor receptor pathway substrate 8
chr2_+_73911477 6.506 STAMBP
STAM binding protein
chr1_+_81544432 6.459 LPHN2
latrophilin 2
chr11_+_12265022 6.436 NM_032867
MICALCL
MICAL C-terminal like
chr2_-_73170290 6.411 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr7_-_135083906 6.411 NM_205855
FAM180A
family with sequence similarity 180, member A
chr12_+_106498763 6.372 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr3_+_185520744 6.317 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr17_-_36928604 6.284 NM_002275
KRT15
keratin 15
chr19_+_43486640 6.248 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr4_-_152366970 6.221 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr10_-_118022965 6.209 NM_005264
GFRA1
GDNF family receptor alpha 1
chr3_-_48607596 6.148 NM_000094
COL7A1
collagen, type VII, alpha 1
chr10_-_90601655 6.040 NM_144590
ANKRD22
ankyrin repeat domain 22
chr10_-_62002672 6.015 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr18_-_72336133 6.003 NM_014643
ZNF516
zinc finger protein 516
chr4_+_183302105 5.974 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr13_-_85271329 5.972 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr7_+_838663 5.965 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr11_-_71458739 5.959 NUMA1
nuclear mitotic apparatus protein 1
chr5_-_134942346 5.940 CXCL14
chemokine (C-X-C motif) ligand 14
chr5_-_134942867 5.862 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr3_+_48482625 5.833 TREX1
three prime repair exonuclease 1
chr1_-_151788341 5.817 NM_002960
S100A3
S100 calcium binding protein A3
chr1_+_84540921 5.786 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr11_-_47502115 5.742 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr21_+_25856311 5.740 MIR155HG
MIR155 host gene (non-protein coding)
chr2_+_169634330 5.714 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_-_1935764 5.692 NM_016358
IRX4
iroquois homeobox 4
chr1_-_28392966 5.686 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr3_+_161877640 5.672 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr2_+_202379442 5.640 NM_139158
CDK15
cyclin-dependent kinase 15
chr6_-_10527772 5.593 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_185064654 5.548 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_+_43971689 5.495 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr6_+_41712907 5.464 MDFI
MyoD family inhibitor
chr22_-_43986896 5.461 KIAA0930
KIAA0930
chr6_+_108593907 5.456 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_-_150564302 5.429 NM_002016
FLG
filaggrin
chr18_-_45630154 5.371 MYO5B
myosin VB
chr1_-_221919982 5.354 CAPN8
calpain 8
chr5_+_145296313 5.334 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr3_+_48482213 5.299 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr17_-_37034288 5.294 NM_000422
KRT17
keratin 17
chr4_+_81325447 5.277 NM_020226
PRDM8
PR domain containing 8
chr11_-_101906640 5.219 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_+_110494654 5.212 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr1_-_117554999 5.189 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_+_150753601 5.175 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr5_+_73145098 5.170 RGNEF
190 kDa guanine nucleotide exchange factor
chr8_+_70567634 5.150 SULF1
sulfatase 1
chr16_-_73859451 5.112 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr2_-_202271598 5.099 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr5_+_59819761 5.073 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chrX_-_19598912 5.034 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr18_+_59705918 4.956 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr11_+_696607 4.943 EPS8L2
EPS8-like 2
chr10_-_105228986 4.943 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr19_-_60573552 4.941 NM_000641
IL11
interleukin 11
chr4_-_122304925 4.936 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr3_+_185521139 4.883 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr1_+_24518501 4.840 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr11_-_76676110 4.774 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr11_+_101423378 4.769 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr6_+_121798443 4.759 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr11_-_117640078 4.721


chr8_+_120289735 4.711 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_-_104696678 4.693 NM_182691
SRPK2
SRSF protein kinase 2
chr6_+_74462654 4.691 CD109
CD109 molecule
chr7_+_1543644 4.685 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr11_-_117640166 4.671 MPZL2
myelin protein zero-like 2
chr12_-_102967828 4.661 GLT8D2
glycosyltransferase 8 domain containing 2
chr11_-_119499188 4.604 TRIM29
tripartite motif containing 29
chr3_+_190147633 4.597 TPRG1
tumor protein p63 regulated 1
chr14_+_62740878 4.591 NM_020663
RHOJ
ras homolog gene family, member J
chr5_-_148422799 4.580 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr3_+_185377341 4.543 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_+_24518398 4.477 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr5_-_139992621 4.458 NM_000591
CD14
CD14 molecule
chr17_-_26665213 4.426 EVI2B
ecotropic viral integration site 2B
chr1_+_148747110 4.373 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr19_-_56204615 4.363 NM_012315
KLK9
kallikrein-related peptidase 9
chr19_-_48661563 4.361 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr17_-_24069299 4.348 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr12_-_51912101 4.345 NM_000966
RARG
retinoic acid receptor, gamma
chr3_-_150578207 4.328 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_150578103 4.322 TM4SF1
transmembrane 4 L six family member 1
chr12_-_90097384 4.282 NM_133503
DCN
decorin
chr4_-_54119159 4.267 NM_032622
LNX1
ligand of numb-protein X 1
chr8_+_70567581 4.267 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr16_-_30983909 4.239 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr2_+_33213111 4.211 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr9_-_90983501 4.197 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr8_-_108579270 4.149 NM_001146
ANGPT1
angiopoietin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.78 5.26e-05 GO:0009888 tissue development
1.35 1.62e-04 GO:0048856 anatomical structure development
1.36 5.01e-04 GO:0048731 system development
1.29 8.60e-04 GO:0032502 developmental process
1.30 1.81e-03 GO:0007165 signal transduction
1.30 1.90e-03 GO:0007275 multicellular organismal development
8.13 3.20e-03 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
9.05 5.71e-03 GO:0031581 hemidesmosome assembly
2.20 5.76e-03 GO:0061061 muscle structure development
1.27 6.23e-03 GO:0023052 signaling
1.59 8.68e-03 GO:0042127 regulation of cell proliferation
1.40 9.11e-03 GO:0048513 organ development
2.40 9.24e-03 GO:0008544 epidermis development
1.60 1.14e-02 GO:0009611 response to wounding
2.32 3.57e-02 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 9.55e-04 GO:0005576 extracellular region
1.24 1.76e-03 GO:0005886 plasma membrane
1.23 3.55e-03 GO:0071944 cell periphery
1.52 4.75e-03 GO:0044421 extracellular region part
1.38 1.59e-02 GO:0005856 cytoskeleton
5.42 2.00e-02 GO:0001533 cornified envelope
1.31 2.03e-02 GO:0044459 plasma membrane part
1.87 4.02e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.16e-02 GO:0005515 protein binding